Open AccessCOVID-19, septic shock and syndrome of disseminated intravascular coagulation syndrome. Part 1
Author(s) -
Victoria Bitsadze,
J. Kh. Khizroeva,
Alexander Makatsariya,
Е. V. Slukhanchuk,
M. V. Tretyakova,
Giuseppe Rizzo,
JeanChristophe Gris,
Ismaı̈l Elalamy,
В. Н. Серов,
A. S. Shkoda,
Н. В. Самбурова
Publication year - 2020
Publication title -
vestnik rossijskoj akademii medicinskih nauk
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.122
H-Index - 15
eISSN - 2414-3545
pISSN - 0869-6047
DOI - 10.15690/vramn1335
Subject(s) - disseminated intravascular coagulation , septic shock , cytokine storm , medicine , systemic inflammatory response syndrome , immunology , sepsis , thrombosis , inflammation , disease , neutrophil extracellular traps , shock (circulatory) , coagulation , intensive care medicine , covid-19 , infectious disease (medical specialty) , pathology
The pandemic of a new coronavirus infection (Coronavirus Disease 2019, COVID-19) caused by SARS-CoV-2 became a real challenge to humanity and the medical community in 2020 and raised a number of medical, social and even philosophical questions. An almost avalanche-like increase in the number of infected people in a short time, due to the high contagiousness of viral infection, allowed us to identify groups of patients with mild, moderate and severe forms of the disease. Doctors around the world are faced with an acute problem of treating a large number of patients in critical conditions caused by COVID-19.
From the currently available information on clinical cases of COVID-19, it follows that COVID-19 patients in critical condition have a clinical picture of disseminated intravascular coagulation (DIC), septic shock with the development of multiple organ failure.
The first part of the article discusses the pathogenesis of non-specific universal biological responses of the body in critical condition - from the Sanarelli-Schwartzman phenomenon to the DIC, septic shock, systemic inflammatory response syndrome and the so-called neutrophil extracellular traps (NETs). The questions of cytokine storm in severe forms of systemic inflammatory response syndrome (SIRS), the role of inflammation in the activation of coagulation, and the relationship between inflammation and thrombosis are discussed. Modern ideas about the mechanisms of so-called NETosis, their role in the occurrence of immunothrombosis and inflammation-induced thrombosis in autoimmune diseases - vasculitis, antiphospholipid syndrome, and systemic lupus erythematosus is highlighted. The article discusses the possibility of participation of ADAMTS-13 metalloproteinase in the pathogenesis of multiple organ failure in severe endotheliopathy in patients with viral septic shock.