Open AccessThe pathomorphosis of inflammatory bowel diseases
Author(s) -
И. В. Маев,
Маев Игорь Вениаминович,
Yurii A. Shelygin,
Шелыгин Юрий Анатольевич,
M. I. Skalinskaya,
Скалинская Мария Игоревна,
А. В. Веселов,
Веселов Алексей Викторович,
Е. В. Сказываева,
Сказываева Екатерина Васильевна,
Irina A. Rasmagina,
Расмагина Ирина Алексеевна,
D Komarova,
Комарова Диана Андреевна,
И. Г. Бакулин,
Бакулин Игорь Геннадьевич
Publication year - 2020
Publication title -
vestnik rossijskoj akademii medicinskih nauk
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.122
H-Index - 15
eISSN - 2414-3545
pISSN - 0869-6047
DOI - 10.15690/vramn1219
Subject(s) - medicine , ulcerative colitis , inflammatory bowel disease , disease , inflammatory bowel diseases , pharmacotherapy , incidence (geometry) , intervention (counseling) , intensive care medicine , quality of life (healthcare) , crohn's disease , differential diagnosis , pathology , physics , nursing , psychiatry , optics
Inflammatory bowel diseases (IBD) are immune-mediated diseases and usually manifest at a young age. They are requires in a long-term treatment or surgery with a high probability of surgical intervention. IBDs are accompanied by a decrease in working capacity, impaired quality of life and social disadaptation. However, timely diagnosis with using modern diagnostic methods, the use of evidence-based immunosuppressive and biological therapy significantly changed the pathomorphosis of this disease. But despite the achievements of the pharmacotherapy, the incidence and prevalence of IBD are still increasing, a demand for surgery remains both for Crohn`s disease and ulcerative colitis throughout all the period of illness. At the same time there is a trend towards the variability of symptoms, mismatch of the clinical symptoms with the real severity of inflammation, increase of a number of patients with extraintestinal manifestations and resistance to induction and maintenance therapies. In addition to this, the observation of this group of patients is complicated due to the difficulty of the early diagnosis and differential analysis of IBD, the need of early induction treatment according to the guidelines and the lack of adherence to the therapy.