Open AccessDepression and Cardiovascular Diseases
Author(s) -
Nurauralieva,
D. А. Napalkov
Publication year - 2014
Publication title -
vestnik rossijskoj akademii medicinskih nauk
Language(s) - English
Resource type - Journals
eISSN - 2414-3545
pISSN - 0869-6047
DOI - 10.15690/vramn.v69i9-10.1127
Subject(s) - depression (economics) , medicine , proinflammatory cytokine , endocrine system , disease , heart failure , stroke (engine) , coronary heart disease , immune system , inflammation , intensive care medicine , immunology , hormone , mechanical engineering , engineering , economics , macroeconomics
Depression is considered to be an independent cardiovascular risk factor and it may worsen the symptoms of already established cardiovascular pathology such as coronary heart disease, chronic heart failure, stroke and hypertension. 3 key psychobiological mechanisms by means of which depression influences cardiovascular system: disbalance in stress response of endocrine system, hyperregulation of autonomic nervous system and immune disorders leading to dysregulation of acute phase proteins and proinflammatory cytokines release. In majority of studies in patients with depression and cardiovascular diseases it was shown that antidepressants improve the symptoms. By the way, in some studies controversial results were obtained. Future studies in this direction with involvement of cardiologists and psychiatrists should be held.