Open AccessTHE CONTRIBUTION OF GENES POLYMORPHISM OF THROMBOPHILIA IN CLINICAL VARIABILITY OF HEMORRHAGIC VASCULITIS
Author(s) -
Л. В. Жданова,
Lev I. Patrushev,
В. В. Долгих,
Аюр Бато-жаргалович Бимбаев,
Ольга Чингисовна Хойкова
Publication year - 2015
Publication title -
vestnik rossijskoj akademii medicinskih nauk
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.122
H-Index - 15
eISSN - 2414-3545
pISSN - 0869-6047
DOI - 10.15690/vramn.v69.i3-4.997
Subject(s) - medicine , vasculitis , thrombophilia , rash , lupus anticoagulant , immunology , petechial rash , gastroenterology , disease , thrombosis , surgery
Background: The article is devoted to the study of clinical and laboratory characteristics of the current of hemorrhagic vasculitis in children in the Republic of Buryatia. Patients and methods: The study included 27 patients aged 7,6±4,02 years, who conducted clinical and laboratory tests, immunological study of antiphospholipids of antibodies, genetic testing for thrombophilia markers of candidate genes. Results: The results showed that hemorrhagic vasculitis often affects children of Buryat nationality. In 96% of cases there are mixed clinical forms of the disease. 63% of children of hemorrhagic vasculitis preceded by various factors, a higher percentage of infectious diseases. The first clinical symptom in 63% of patients is a typical purpura hemorrhagic rash. Results of clinical laboratory blood tests revealed no significant deviations. Circulation of lupus anticoagulant was detected in 37% of subjects . The аCL IgM detected in 3 children, aβ2-GP-I IgA — in 4 , aβ2-GP-I IgM — in 1 patient. Carriers of thrombophilia polymorphisms were in 95% of children. Noted that homozygous variants of genes polymorphisms of methylenetetrahydrofolateredreductase and plasminogen activator inhibitor-1 correlate with the presence of urinary symptoms and recurrence of the rash. Conclusion: The study shows the risk of recurrent flow of hemorrhagic vasculitis and nefritis of Henoch–Schonlein in children with thrombophilia gene polymorphism.