Open AccessIMMUNOPHENOTYPIC CHARACTERISTIC OF DENDRITIC CELLS IN BRONCHIAL ASTHMA IN CONDITIONS OF EXTRACT OPISTHORCHIS FELINEUS IN VITRO
Author(s) -
Kremer Eé,
Ogorodova Lm,
Kirillova Na,
Khvorilova Kv,
Perevozchikova Tv,
Faĭt Ea
Publication year - 2013
Publication title -
vestnik rossijskoj akademii medicinskih nauk
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.122
H-Index - 15
eISSN - 2414-3545
pISSN - 0869-6047
DOI - 10.15690/vramn.v68i5.665
Subject(s) - cd86 , opisthorchiasis , in vitro , immunology , biology , antigen , dendritic cell , immune system , microbiology and biotechnology , medicine , t cell , pathology , biochemistry
This work shows comparative characteristics of immunogenic properties of the extract of Opisthorchis felineus in different severity of asthma using antigen presenting dendritic cells in vitro. New data on the effect of Opisthorchis felineus on the expression of surface markers of dendritic cells (CD209, HLA-DR, CD83, CD86) were received. Pronounced expression of CD209, CD86 and HLA-DR on the surface of dendritic cells in mild and severe asthma compared with healthy individuals was shown. In the stimulation of dendritic cells with extract Opisthorchis felineus in vitro weakening of CD86 expression in mild and in severe asthma was found. CD86 molecule may be a regulatory factor in the co-stimulation of dendritic cells which