Open AccessCELL THERAPY OF CRITICAL LIMB ISCHEMIA (PROBLEMS AND PROSPECTS)
Author(s) -
С. В. Лебедев,
A. V. Karasev,
V. V. Kungurtsev,
Анастасия Вячеславовна Лохонина,
Е Б Клейменова
Publication year - 2013
Publication title -
vestnik rossijskoj akademii medicinskih nauk
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.122
H-Index - 15
eISSN - 2414-3545
pISSN - 0869-6047
DOI - 10.15690/vramn.v68i3.598
Subject(s) - critical limb ischemia , ischemia , medicine , progenitor cell , stem cell therapy , etiology , intensive care medicine , stem cell , limb ischemia , pathogenesis , surgery , arterial disease , cardiology , pathology , vascular disease , transplantation , biology , genetics
Critical limb ischemia is a syndrome that combines several peripheral artery diseases with different ethiology and pathogenesis but with similar prognosis, high morbidity and mortality. Possibility of surgical and conservative treatment of critical limb ischemia almost completely exhausted. Some hopes have arisen due to progress in cell technology. The article provides a critical analysis of pathogenic prerequisites of stem/progenitor cells for the treatment of patients with a critical limb ischemia in detail the basic results of preclinical and clinical studies on the safety and efficacy of cell technology. Unsolved problems and prospects of practical application are also discussed.