CELL THERAPY OF CRITICAL LIMB ISCHEMIA (PROBLEMS AND PROSPECTS) | Zendy

S.V. Lebedev | Zendy; A. V. Karasev | Zendy; V. V. Kungurtsev | Zendy; Анастасия Вячеславовна Лохонина | Zendy; Е Б Клейменова | Zendy

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CELL THERAPY OF CRITICAL LIMB ISCHEMIA (PROBLEMS AND PROSPECTS)

Author(s) -

S.V. Lebedev,

A. V. Karasev,

V. V. Kungurtsev,

Анастасия Вячеславовна Лохонина,

Е Б Клейменова

Publication year - 2013

Publication title -

annals of the russian academy of medical sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.122

H-Index - 15

eISSN - 2414-3545

pISSN - 0869-6047

DOI - 10.15690/vramn.v68i3.598

Subject(s) - critical limb ischemia , ischemia , medicine , progenitor cell , stem cell therapy , etiology , intensive care medicine , stem cell , limb ischemia , pathogenesis , surgery , arterial disease , cardiology , pathology , vascular disease , transplantation , biology , genetics

Critical limb ischemia is a syndrome that combines several peripheral artery diseases with different ethiology and pathogenesis but with similar prognosis, high morbidity and mortality. Possibility of surgical and conservative treatment of critical limb ischemia almost completely exhausted. Some hopes have arisen due to progress in cell technology. The article provides a critical analysis of pathogenic prerequisites of stem/progenitor cells for the treatment of patients with a critical limb ischemia in detail the basic results of preclinical and clinical studies on the safety and efficacy of cell technology. Unsolved problems and prospects of practical application are also discussed.

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