Open AccessMolecular and pharmacogenetic mechanisms of severe asthma
Author(s) -
Е. С. Куликов,
Л. М. Огородова,
Maxim B. Freidin,
И. А. Деев,
Полина Александровна Селиванова,
С. В. Федосенко,
Н. А. Кириллова
Publication year - 2013
Publication title -
vestnik rossijskoj akademii medicinskih nauk
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.122
H-Index - 15
eISSN - 2414-3545
pISSN - 0869-6047
DOI - 10.15690/vramn.v68i3.596
Subject(s) - pharmacogenetics , asthma , medicine , intensive care medicine , personalized medicine , disease , persistence (discontinuity) , bioinformatics , immunology , biology , genotype , gene , genetics , geotechnical engineering , engineering
This review summarizes the results of studies to identify the dominant mechanisms of development and persistence of inflammation in severe asthma and results of pharmacogenetic studies of determination response to drugs. These mechanisms could potentially be used for diagnostic purposes and become the new targets of asthma therapy. Pharmacogenetic information will enable the use of a personalized approach to the asthma management which will adjust the therapy technology and increase the possibility of achieving disease control.