Molecular and pharmacogenetic mechanisms of severe asthma | Zendy

Е. С. Куликов | Zendy; Л. М. Огородова | Zendy; Maxim B. Freidin | Zendy; И. А. Деев | Zendy; П. А. Селиванова | Zendy; С. В. Федосенко | Zendy; Н. А. Кириллова | Zendy

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Molecular and pharmacogenetic mechanisms of severe asthma

Author(s) -

Е. С. Куликов,

Л. М. Огородова,

Maxim B. Freidin,

И. А. Деев,

П. А. Селиванова,

С. В. Федосенко,

Н. А. Кириллова

Publication year - 2013

Publication title -

annals of the russian academy of medical sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.122

H-Index - 15

eISSN - 2414-3545

pISSN - 0869-6047

DOI - 10.15690/vramn.v68i3.596

Subject(s) - pharmacogenetics , asthma , medicine , intensive care medicine , personalized medicine , disease , persistence (discontinuity) , bioinformatics , immunology , biology , genotype , gene , genetics , geotechnical engineering , engineering

This review summarizes the results of studies to identify the dominant mechanisms of development and persistence of inflammation in severe asthma and results of pharmacogenetic studies of determination response to drugs. These mechanisms could potentially be used for diagnostic purposes and become the new targets of asthma therapy. Pharmacogenetic information will enable the use of a personalized approach to the asthma management which will adjust the therapy technology and increase the possibility of achieving disease control.

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