Open AccessCEREBROLYSIN FOR ACUTE ISCHEMIC STROKE
Author(s) -
L E iganshina,
Tatyana Abakumova
Publication year - 2013
Publication title -
vestnik rossijskoj akademii medicinskih nauk
Language(s) - Uncategorized
Resource type - Journals
eISSN - 2414-3545
pISSN - 0869-6047
DOI - 10.15690/vramn.v68i1.533
Subject(s) - cerebrolysin , stroke (engine) , medicine , ischemic stroke , cardiology , ischemia , engineering , aerospace engineering
The review discusses existing evidence of benefits and risks of cerebrolysin--a mixture of low-molecular-weight peptides and amino acids derived from pigs' brain tissue with proposed neuroprotective and neurotrophic properties, for acute ischemic stroke. The review presents results of systematic search and analysis of randomised clinical trials comparing cerebrolysin with placebo in patients with acute ischemic stroke. Only one trial was selected as meeting quality criteria. No difference in death and adverse events between cerebrolysin and placebo was established. The authors conclude about insufficiency of evidence to evaluate the effect of cerebrolysin on survival and dependency in people with acute ischemic stroke.