Open AccessPOLYMORPHISM OF GENES OF THE SYSTEM OF BIOTRANSFORMATION OF XENOBIOTICS IN PATIENTS WITH OCCUPATIONAL ALLERGIC DERMATOSES
Author(s) -
Н Ф Измеров,
Lyudmila P. Kuzmina,
М. М. Коляскина,
Людмила Михайловна Безрукавникова,
Нана Анзориевна Лазарашвили,
Яна Александровна Петинати
Publication year - 2012
Publication title -
vestnik rossijskoj akademii medicinskih nauk
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.122
H-Index - 15
eISSN - 2414-3545
pISSN - 0869-6047
DOI - 10.15690/vramn.v67i7.339
Subject(s) - xenobiotic , biotransformation , gene , allele , polymorphism (computer science) , cyp3a4 , biology , genetics , population , gene polymorphism , medicine , endocrinology , environmental health , cytochrome p450 , biochemistry , enzyme , metabolism
Evaluation of genes polymorphic system of xenobiotics biotransformation in patients with оccupational allergodermatoses showed significantly higher percentage of incidence of polymorphic variants of genes CYP 1A1 *2C and EPHX1 AND-415G compared with population control. A combination of 3 or more adverse hetero - and homozygous gene alleles CYP 1A1, CYP3A4, ЕРНХ1 and deletions of genes GSTM1 and GSTT1, is characterized by earlier (with the experience of work in harmful conditions up to 5 years) development, severe and unfavorable prognosis of оccupational pathology of the skin.