POLYMORPHISM OF GENES OF THE SYSTEM OF BIOTRANSFORMATION OF XENOBIOTICS IN PATIENTS WITH OCCUPATIONAL ALLERGIC DERMATOSES | Zendy

Н Ф Измеров | Zendy; Kuz'mina Lp | Zendy; M. M. Kolyaskina | Zendy; Л. М. Безрукавникова | Zendy; N. A. Lazarashvili | Zendy; Y. A. Petinati | Zendy

Open Access

POLYMORPHISM OF GENES OF THE SYSTEM OF BIOTRANSFORMATION OF XENOBIOTICS IN PATIENTS WITH OCCUPATIONAL ALLERGIC DERMATOSES

Author(s) -

Н Ф Измеров,

Kuz'mina Lp,

M. M. Kolyaskina,

Л. М. Безрукавникова,

N. A. Lazarashvili,

Y. A. Petinati

Publication year - 2012

Publication title -

annals of the russian academy of medical sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.122

H-Index - 15

eISSN - 2414-3545

pISSN - 0869-6047

DOI - 10.15690/vramn.v67i7.339

Subject(s) - xenobiotic , biotransformation , gene , allele , polymorphism (computer science) , cyp3a4 , biology , genetics , population , gene polymorphism , medicine , endocrinology , environmental health , cytochrome p450 , biochemistry , enzyme , metabolism

Evaluation of genes polymorphic system of xenobiotics biotransformation in patients with оccupational allergodermatoses showed significantly higher percentage of incidence of polymorphic variants of genes CYP 1A1 *2C and EPHX1 AND-415G compared with population control. A combination of 3 or more adverse hetero - and homozygous gene alleles CYP 1A1, CYP3A4, ЕРНХ1 and deletions of genes GSTM1 and GSTT1, is characterized by earlier (with the experience of work in harmful conditions up to 5 years) development, severe and unfavorable prognosis of оccupational pathology of the skin.

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