Open AccessROLE OF DOPAMINE D1- AND D2-RECEPTORS IN THE DELTA1-OPIOIDERGIC IMMUNOSTIMULATION
Author(s) -
Cheĭdo Ma,
Gevorgian Mm
Publication year - 2012
Publication title -
vestnik rossijskoj akademii medicinskih nauk
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.122
H-Index - 15
eISSN - 2414-3545
pISSN - 0869-6047
DOI - 10.15690/vramn.v67i5.275
Subject(s) - opioidergic , d2 like receptor , dopamine receptor d2 , sch 23390 , receptor , dopamine receptor , pharmacology , dopamine , chemistry , d1 like receptor , agonist , endocrinology , medicine , antagonist , dopamine receptor d3 , biology , (+) naloxone
The study has shown that activation of delta1-opioid receptors by a highly selective peptide agonist DPDPE (100 µg/kg) results in a significant increase of the immune response to antigen (SRBC, 5×108) in CBA mice. SCH-23390 (1 mg/kg), a selective antagonist of the postsynaptic dopamine D1-receptors, and selective D2-blocker haloperidol (1 mg/kg) prevented immunostimulating effect of DPDPE. Comparison of effects of the antagonists suggests that delta1-opioidergic immunostimulation has more significant impact due to involvement of dopamine D1-receptors.