Open AccessTHE DISTRIBUTION OF IODINE-125 LABELED ALPHA-FETOPROTEIN IN THE ANIMAL ORGANISM AND ITS ACCUMULATION IN THE TUMOR
Author(s) -
С Е Северин,
В. Н. Кулаков,
Е. Ю. Москалева,
Е. С. Северин,
I I Slobodianik,
T. P. Klimova
Publication year - 2012
Publication title -
vestnik rossijskoj akademii medicinskih nauk
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.122
H-Index - 15
eISSN - 2414-3545
pISSN - 0869-6047
DOI - 10.15690/vramn.v67i4.193
Subject(s) - alpha fetoprotein , alpha (finance) , spleen , lymphatic system , distribution (mathematics) , pathology , iodine , radioactive iodine , biology , chemistry , medicine , endocrinology , thyroid , hepatocellular carcinoma , mathematical analysis , construct validity , nursing , mathematics , organic chemistry , patient satisfaction
The distribution of iodine-125 labeled human alpha-fetoprotein in mice was studied after its intravenous injection. The maximal accumulation of alpha-fetoprotein in different tissues and organs of animals was observed mainly 5 hours after injection. Then the protein was gradually eliminated from the body. In the liver, intestine and blood of intact animals 125I-alpha-fetoprotein persists for at least three days. Accumulation of alpha-fetoprotein in various tissues and organs may determine the different biological effects of this protein. In the mice with transplanted lymphatic leukemia cells P388 the high level of alpha-fetoprotein accumulation was detected in the tumor tissue, reaching 6% of the injected amount per 1 g of tissue. This allows considering the radionuclide-labeled alpha-fetoprotein as a promising medical radionuclide marker for the radiological detection of malignant tumors.