INTRAHEPATIC INDUCTION OF ENDOGENOUS S-ADENOSYL-L-METHIONINE AGAINST THE BACKGROUND OF VARIOUS WAYS OF ADMINISTRATION OF METHIONINE-SUCCINATE COMPLEX AND ITS ROLE IN DRUG-INDUCED LIVER LESION CORRECTION

A comparative study of the level of endogenous S-adenosyl-L-methionine (SAM) with other hepatoprotectors in pharmacological correction of liver drug lesion. Among 117 male rats. It has been shown that among antituberculous drugs only Remaxol and Runihol were causing significant increase in endogenic SAM. Taking into account the amelioration of lab results as well as histological condition of the liver against the background of Remaxol treatment as well as positive effect of Runihol treatment upon cholestasis, one can draw a conclusion  upon the importance of succinic acid together with SAM induction as a part of hepatoprotective effect of the drug.  Reamberin, which contains succinic acid without methionine also shows hepatoprotective qualities and doesn’t induce endogenous SAM production. Positive therapeutic effect of exogenous SAM regardless the way of administration doesn’t correlate with endogenous SAM induction, and is associated with the external hepatocyte cell membrane restoration.