Open AccessPREVENTION OF TUBERCULOSIS: CURRENT APPROACHES TO DEVELOPMENT OF VACCINES
Author(s) -
Marina Stukova,
Marina Stukova,
Н. В. Заболотных,
Н. В. Заболотных,
Т И Виноградова,
Т И Виноградова,
V. Ya. Gergert,
В Я Гергерт,
А. С. Апт,
А. С. Апт,
В В Ерохин,
А С Капрельянц,
Arseny S. Kaprelyants,
В В Ерохин,
Piotr Yablonskii,
П. К. Яблонский,
О. И. Киселев,
О. И. Киселев
Publication year - 2012
Publication title -
vestnik rossijskoj akademii medicinskih nauk
Language(s) - English
Resource type - Journals
eISSN - 2414-3545
pISSN - 0869-6047
DOI - 10.15690/vramn.v67i11.471
Subject(s) - mycobacterium tuberculosis , mycobacterium bovis , tuberculosis , heterologous , vaccination , virology , tuberculosis vaccines , bcg vaccine , immunology , attenuated vaccine , biology , medicine , genetics , virulence , pathology , gene
This review is focused on recent advances in development of new vaccines for the prevention of tuberculosis. The main reasons for lack of BCG vaccine efficacy in different populations and geographic regions are presented. Design of new vaccines based on live modified strains of Mycobacterium bovis BCG, attenuated strains of Mycobacterium tuberculosis, recombinant proteins and viral vectors is considered in the specific examples. The usage of the heterologous «prime-boost» vaccination strategy against tuberculosis is discussed.