Open AccessINTRACELLULAR TARGETS OF PROAPOPTOTIC INFLUENCE OF GASEOUS TRANSMITTERS
Author(s) -
Tashireva La,
Starikova Eg,
Novitskiĭ Vv,
Riazantseva Nv
Publication year - 2012
Publication title -
vestnik rossijskoj akademii medicinskih nauk
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.122
H-Index - 15
eISSN - 2414-3545
pISSN - 0869-6047
DOI - 10.15690/vramn.v67i10.420
Subject(s) - xiap , jurkat cells , nitric oxide , intracellular , chemistry , mitochondrion , hydrogen sulfide , microbiology and biotechnology , transmembrane protein , apoptosis , voltage dependent anion channel , membrane potential , bcl 2 family , caspase , biophysics , biochemistry , programmed cell death , biology , bacterial outer membrane , immunology , sulfur , receptor , immune system , organic chemistry , t cell , gene , escherichia coli
Main molecular targets of nitric oxide, hydrogen sulfide and carbon monoxide proapoptotic action in Jurkat cells were determined in this study. Decrease of mitochondrial transmembrane potential was shown during all three gases action. Reason of this event is the Bcl-2 family members disbalance. Proapoptotic proteins release after mitochondrion membranes permeabilisation could be abolished by protein xIAP inhibition of caspase -9 and-3 activity during NO and CO application.