MORPHOFUNCTIONAL FEATURES OF THE PLACENTA OF NEWBORNS IN BIRTH-INDUCED CRITICAL CONDITIONS: THE RESULTS OF A RETROSPECTIVE COHORT STUDY

Background.  The placenta condition is the health marker of newborns  and it can be considered  in the early diagnosis  of the development of severe pathological conditions in a child. Objective:  Our aim was to study the relationship between the placenta characteristics and the risk of a birth-induced critical condition in a child and the risk of having children with the APGAR score of 4 points) were singled out. In multivariate analysis, it was established  that the appearance  of a birth-induced  critical condition with the APGAR score < 4 points was associated with pathological attachment of the umbilical cord (odds ratio, OR, 2.8, 95% confidence interval, CI, 1.1–7.0),  placenta weight (OR 5.4, 95% CI 1.9–14.9),  signs of chronic fetoplacental  insufficiency (OR 7.3, 95% CI 2.9–18.8), impaired blood circulation in the placenta (OR 13.7, 95% CI 4.7–39.3), placental hypoplasia (OR 8.9, 95% CI 2.4–32.4), fetal-placental  ratio (OR 8.9, 95% CI 2.4–32.4)  as well as low birth weight of a newborn (OR 2.9, 95% CI 1.2–6.9).  Conclusion. Morphological characteristics of the placenta are prognostic markers for the development of critical conditions with the APGAR score at birth < 4 points.