Open AccessBiochemical and immunological blood parameters in patients with inflammatory complications after spine screw fixation
Author(s) -
Volodymyr Radchenko,
Frieda Leontyeva,
Oleksandr Barkov,
Vladyslav Tuliakov,
Mykola Korzh
Publication year - 2021
Publication title -
ortopediâ, travmatologiâ i protezirovanie/ortopediâ, travmatologiâ i protezirovanie
Language(s) - English
Resource type - Journals
eISSN - 2518-1882
pISSN - 0030-5987
DOI - 10.15674/0030-59872021223-27
Subject(s) - medicine , haptoglobin , inflammation , soft tissue , lymphocyte , surgery , sialic acid , alkaline phosphatase , fixation (population genetics) , immune system , erythrocyte sedimentation rate , gastroenterology , pathology , immunology , population , biology , biochemistry , genetics , environmental health , enzyme
As a result of screw fixation at the surgical treatment of patients with spinal diseases, certain complications may occur, of which soft tissues inflammation is frequent. Therefore, it is especially important to study the metabolic status of patients before surgery to determine the increased possibility of complications. Objective. To study the biochemical and immunological blood serum parameters and determine their diagnostic sensitivity in patients with the thoracic and lumbar spine diseases after screw fixation with postoperative inflammatory response. Methods. Comparisons of blood parameters were carried out in two groups of 20 patients in each group: the first one — patients at whom the postoperative period passed without complications, the second group — a soft tissues inflammation around the metal structure was observed in the postoperative period. Blood for the study was taken before the surgery on an empty stomach for determination of: C-reactive protein (CRP), sialic acid, alkaline phosphatase (ALP) activity, haptoglobin, content of total chondroitin sulfate (ChS), glycoproteins, circulating immune complexes (CIC), the rate of spontaneous lymphocyte migration, the level of lymphocyte migration with antibodies to bone and cartilage antigens. For quantitative characterization of diagnostic reliability of laboratory test was used the criterion of diagnostic sensitivity. Results. In patients with postoperative soft tissue inflammation around the metal device before surgery, the following indicators were the most informative: the content of ChS (95 %), CRP (80 %), glycoproteins (95 %), haptoglobin (92 %), ALP activity (80 %), sialic acid content (90 %), CIC concentration (70 %), the rate of spontaneous lymphocyte migration (65 %). Conclusions. The laboratory parameters complex with the highest diagnostic sensitivity can be recommended for the selection of preventive measures in the preoperative period, which will improve the results of surgical treatment, reduce its duration and costs.