Open AccessImmunological properties of the bacterial origin compounds
Author(s) -
А. Kapustyan,
N. Cherno
Publication year - 2016
Publication title -
harčova nauka ì tehnologìâ
Language(s) - English
Resource type - Journals
eISSN - 2409-7004
pISSN - 2073-8684
DOI - 10.15673/fst.v10i3.175
Subject(s) - teichoic acid , bacteria , microorganism , peptidoglycan , cell wall , immune system , microbiology and biotechnology , bacterial cell structure , chemistry , lysis , enzyme , biochemistry , biology , immunology , genetics
It is shown that microorganisms are an integral element of the mаcroorganism immune system.Peptidoglycan, muramyldypeptyd, teichoic acids are structural components of cell walls of microorganisms. These componentsare an object for recognition of the innate immunity system. The necessity of the bacteria cell walls destruction with a view toobtain the immunotropic products for enteral consumption, able to overcome the intestinal barrier, was substantiated.The use of lactic acid bacteria (ICD) for such purposes is perspective and safe, since the considerable experience oftheir cultivation was accumulated, in addition, ICD have got «GRAS» (Generally Recognized As Safe) status. Waste productsof ICD are organic acids, hydrogen peroxide, bacteriocins and others. These substances have got antagonist activity, implicitlyaffect on the immune system, reducing the antigenic load caused by pathogenic microorganisms.A number of physical, chemical and biochemical methods of bacteria cell walls destruction were considered. Thepriority methods is the soft influence, namely the use of specific enzymes or hydrolases, own autolyzins with a combination ofphysical destruction methods.