Phản ứng aldol hóa chọn lọc lập thể

Abstract The asymmetric organocatalytic aldol reaction is one of the most important C‐C bond forming tools with the high control of diastereosectivity and/or enantioselectivity. Recent developments of chiral organocatalyst systems allowed the aldol reaction to be carried out under mild conditions, giving products in high yield and diasteroselectivity/enantioselectivity with very good tolerance of functional groups. This review offers an overview about some important advances of asymmetric aldol reaction due to the development of new chiral organocatalysts. Some aspects in green chemistry of aldol reaction are discussed in this review. In addition, several practical applications of the asymmetric aldol reaction in the total synthesis of complex molecules, such as bioactive natural products and pharmaceuticals, are described in this review.