Open AccessPIPERINE-LOADED CHITOSAN NANOPARTICLES: PREPARATION AND CHARACTERIZATION
Author(s) -
Tran Thi Yen Nhi,
Cong Duc Trinh,
Thien Truong,
Tuan Le Quang,
Hanh Bich Pham,
Thuy Thi Lai,
Ha Thi Thanh Le
Publication year - 2021
Publication title -
vietnam journal of science and technology/science and technology
Language(s) - English
Resource type - Journals
eISSN - 2815-5874
pISSN - 2525-2518
DOI - 10.15625/2525-2518/59/4/15523
Subject(s) - piperine , dispersity , dynamic light scattering , nanoparticle , chitosan , transmission electron microscopy , particle size , chemistry , zeta potential , nuclear chemistry , materials science , chemical engineering , nanotechnology , polymer chemistry , organic chemistry , engineering
– HCTN7. Plasma cholesterol level plays an important role in atherosclerosis and cardiovascular diseases. Piperine, an alkaloid form of black pepper is known to reduce cholesterol uptake. In this paper, piperine-loaded chitosan nanoparticles (CTS-PIP NPs) were prepared by ionic gelation method. Molecular interactions among the components were confirmed by FT-IR spectroscopy. Transmission electron microscopy (TEM) images revealed spherical-shaped nanoparticles with diameter of <100 nm. CTS-PIP NPs displayed positive ζ-potential(ZP) of about 31.6 mV. Dynamic light scattering (DLS) particle size (PS) distribution analysis indicated the mean particle size of CTS-PIP NPs was 245.9 nm, polydispersity index of 31%