Open AccessLIGNANS FROM LEAVES OF AMESIODENDRON CHINENSE AND THEIR CYTOTOXIC ACTIVITY
Author(s) -
Ho Van Ban,
Trinh Thi Thanh Van,
Vu Van Chien,
Nguyễn Thị Huệ,
Phạm Thị Hằng,
Nguyen Le Tuan,
Nguyễn Xuân Nhiệm,
Phạm Văn Cường,
Nguyễn Quốc Vượng
Publication year - 2020
Publication title -
vietnam journal of science and technology/science and technology
Language(s) - English
Resource type - Journals
eISSN - 2815-5874
pISSN - 2525-2518
DOI - 10.15625/2525-2518/58/4/14877
Subject(s) - cytotoxic t cell , cancer cell lines , stereochemistry , ic50 , chemistry , traditional medicine , cytotoxicity , cell culture , cancer cell , biology , in vitro , cancer , biochemistry , genetics , medicine
From leaves of Amesiodendron chinense (Mer.) Hu four lignans (+)-aptosimon (1), (+)-isolariciresinol (2), (-)-cleomiscosin A (3), and (-)-cleomiscosin C (3) were isolated. Their structures were determined by spectroscopic analysis including MS, 1D and 2D NMR as well as by comparison with reported data in literature. All compounds were evaluated for cytotoxic activities against five human cancer cell lines, KB, SK-LU-1, MCF-7, HepG-2, and SW-480. They showed weak cytotoxic activity on five tested human cancer cell lines with IC50 values ranging from 32.61 to 95.18 µg/ml.