Open Accesschemical constituents from methanolic extract of Garcinia mackeaniana leaves and their antioxidant activity
Author(s) -
Hà Nguyễn Thị Thu,
Cuong Pham Van,
T. Nguyen Thanh,
Anh Le Thi Tu,
Cham Ba Thi,
Ninh The Son
Publication year - 2020
Publication title -
vietnam journal of science and technology/science and technology
Language(s) - English
Resource type - Journals
eISSN - 2815-5874
pISSN - 2525-2518
DOI - 10.15625/2525-2518/58/4/14680
Subject(s) - benzophenone , chemistry , amentoflavone , dpph , antioxidant , phytochemical , vitexin , rutin , derivative (finance) , phenol , organic chemistry , flavonoid , garcinia , stereochemistry , traditional medicine , chromatography , biochemistry , medicine , financial economics , economics
A phytochemical investigation of the methanolic extract of Garcinia mackeaniana leaves led to the isolation, and determination of five secondary metabolites, including one benzophenone 4,3',4'-trihydroxy-2,6-dimethoxybenzophenone (1), two flavone C-glucosides vitexin (2) and its 2''-O-acetyl derivative (3), one biflavone amentoflavone (4), and one mono-phenol methyl protocatechuate (5). The chemical structures of these compounds were characterized by the NMR-spectroscopic method. These isolated compounds were isolated from G. mackeaniana species for the first time. Benzophenone derivative 1 has shown to be associated with a significant IC50 value of 14.97±0.8 µg/mL in the DPPH-antioxidant assay.