Open AccessNEW QUINAZOLINONE DERIVATIVES: SYTHESIS AND IN VITRO CYTOTOXIC ACTIVITY
Author(s) -
Tran Khac Vu
Publication year - 2020
Publication title -
vietnam journal of science and technology/science and technology
Language(s) - English
Resource type - Journals
eISSN - 2815-5874
pISSN - 2525-2518
DOI - 10.15625/2525-2518/58/1/14391
Subject(s) - quinazolinone , cytotoxic t cell , chemistry , in vitro , cancer cell lines , cytotoxicity , cell culture , combinatorial chemistry , bioassay , ic50 , pharmacology , stereochemistry , cancer cell , cancer , biochemistry , biology , medicine , genetics
The paper presents a simple synthesis of new quinazolinone derivatives 13a-i. Synthesized derivatives were tested for their cytotoxic effect against three cancer cell lines including SKLU-1, MCF-7 and HepG-2. The bioassay result showed that only compound 13e exhibited significant cytotoxic effect against cancer cell lines tested with IC50 values of 9.48, 20.39 and 18.04 µg/ mL, respectively.