Open AccessEFFECT OF HIGH GLUCOSE-INDUCED HYPERGLYCEMIA ON VIRAL HAEMORRHAGIC SEPTICAEMIA VIRUS (VHSV) INFECTION IN ADULT ZEBRAFISH
Author(s) -
Tran Van Cuong,
Nguyen Thi Kim Thoa,
Nguyen Thi Kim Thoa
Publication year - 2020
Publication title -
vietnam journal of science and technology/science and technology
Language(s) - English
Resource type - Journals
eISSN - 2815-5874
pISSN - 2525-2518
DOI - 10.15625/2525-2518/58/1/13530
Subject(s) - zebrafish , virology , virus , biology , viral infection , gene , biochemistry
This study, we conducted a high glucose immersion protocol to induce hyperglycemic zebrafish, later on, with the aim to evaluate the relationship between hyperglycemia and VHSV infection using the zebrafish model. As the results, zebrafish immersed in a 2000 ppm glucose solution for 10 days, FBG has increased two times as compared to control. In addition, hyperglycemic zebrafish was more susceptible to the virus infection resulted in increased the viral mRNA expression levels as well as the viral copy number as 1.7 Log higher than control.