Open AccessCHEMICAL AND PHARMACOLOGICAL EVALUATION OF MANGLICOLOUS LICHEN GRAPHIS AJAREKARII PATW. & C. R. KULK.
Author(s) -
Haritha Polimati,
Sunil Kumar Patnaik,
Vinay Bharadwaj Tatipamula
Publication year - 2019
Publication title -
vietnam journal of science and technology/science and technology
Language(s) - English
Resource type - Journals
eISSN - 2815-5874
pISSN - 2525-2518
DOI - 10.15625/2525-2518/57/3/13679
Subject(s) - cytotoxicity , lichen , antioxidant , dpph , chemistry , superoxide , biochemistry , cell culture , cancer cell lines , radical , isolation (microbiology) , stereochemistry , cancer cell , biology , enzyme , cancer , botany , microbiology and biotechnology , genetics , in vitro
The chemical examination of ethanolic extract of manglicolous lichen Graphis ajarekarii (Ga-Et) resulted in isolation of three known metabolites – chiodectonic acid (1), graphenone (2) and graphisquinone (3). All the isolates (1-3) and Ga-Et were screened against DPPH and superoxide free radicals, six different cancer cell lines and one normal human cell line (NHME). This work is the first report of antioxidant and cytotoxicity studies on the isolated metabolites (1-3).