Open AccessCHOLESTANE-TYPE STEROIDS FROM THE OCTOCORAL Verrucella corona
Author(s) -
Ninh Thị Ngọc,
Trần Thị Hồng Hạnh,
Nguyen Xuan Cuong,
Nguyen Van Thanh,
Đỗ Thị Thảo,
Nguyễn Hoài Nam,
Đỗ Công Thung,
Phan Văn Kiệm,
Châu Văn Minh
Publication year - 2018
Publication title -
vietnam journal of science and technology/science and technology
Language(s) - English
Resource type - Journals
eISSN - 2815-5874
pISSN - 2525-2518
DOI - 10.15625/2525-2518/56/4a/12754
Subject(s) - cholestane , lncap , cytotoxicity , chemistry , methanol , stereochemistry , chromatography , biochemistry , organic chemistry , cancer cell , in vitro , cancer , medicine
Using various chromatographic separations, three cholestane-type steroids were isolated from the methanol extract of the octocoral Verrucella corona. Their structures were elucidated to be (22E)-cholesta-5,22-dien-3β-ol-7-one (1), trans-liagosterol (2), and guggulsterol-II (3), by detailed analysis of the 1D and 2D-NMR data as well as comparison with those reported. Among them, compound 2 showed significant cytotoxicity against eight human cancer cell lines as HepG2, HL-60, KB, LNCaP, LU-1, MCF7, SK-Mel2, and SW480.