Open AccessTHE PROTECTIVE EFFECT OF SOME FRACTIONS AND ISOLATED COMPOUNDS FROM EUPHORBIA HIRTA L. ON PANCREATIC β-CELLS MIN6
Author(s) -
Bach Thi Le,
Dung Tien Le,
Tuan Nguyen,
Thanh Q. C. Nguyen,
Leclercq Joëlle Quetin,
Buu Hue Thi Bui
Publication year - 2018
Publication title -
vietnam journal of science and technology/science and technology
Language(s) - English
Resource type - Journals
eISSN - 2815-5874
pISSN - 2525-2518
DOI - 10.15625/2525-2518/56/4a/12753
Subject(s) - quercitrin , euphorbia , traditional medicine , quercetin , chemistry , luteolin , euphorbiaceae , methanol , biology , botany , biochemistry , antioxidant , organic chemistry , medicine
Euphorbia hirta L., a kind of herbs belonging to family Euphorbiaceae, has been found a lot in the Mekong Delta. From the ethyl acetat and methanol fractions of this plant, four pure compounds were isolated and identified their chemical structure by spectroscopic techniques including quercitrin (1), luteolin (2), quercetin (3) and caffeic acid (4). The effect of crude ethanolic extract and some fractioned extracts as well as four isolated compounds from E hirta L., collected in the Mekong Delta, on endoplasmic reticulum stress-induced cell death in mouse β-cell lines was investigated. The results showed that methanol fraction and a isolated compound, quercitrin gave strong cell-protective effect with the cell viability of 69% and 78% at the dose of 100 µg/mL and 10 µg/mL, respectively. This proves that E hirta L. might have anti-diabetic effects and worth conducting further pharmacological investigations related to type 2 diabetes mellitus.