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New Strategies of Photoprotection
Author(s) -
Verschooten Lien,
Claerhout Sofie,
Laethem An,
Agostinis Patricia,
Garmyn Marjan
Publication year - 2006
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1562/2006-04-27-ir-884
Subject(s) - photoprotection , photoaging , sunburn , dna damage , endogeny , dna repair , antioxidant , chemistry , biology , dna , biochemistry , dermatology , medicine , genetics , photosynthesis
Adequate photoprotection is essential to control UV‐related disorders, including sunburn, photoaging and photocarcinogenisis. Sun avoidance, protection of skin with clothing, and sunscreens are presently the best way of photoprotection, assuming that they are used properly. However, new strategies, which are based on or make use of the endogenous protective response to UV light, may further improve currently used photoprotective means. The addition of repair enzymes and/or antioxidants has a positive effect on skin's recovery from UV‐induced DNA‐damage. Several botanical agents, mainly vitamins and polyphenols, have shown to influence signal transduction pathways leading to photo‐protective effects. Also stimulation of endogenous UV‐response pathways via irradiation with a low UV dose or via simulation of UV‐induced DNA‐damage results in photo‐protective effects. Future research in this field and combination of different photoprotective strategies will hopefully lead to improved photoprotection.