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Photobiological Information Obtained from XPA Gene‐deficient Mice †
Author(s) -
Horio Takeshi,
MiyauchiHashimoto Hiroko,
Kuwamoto Kazue,
Yamazaki Fumikazu,
Okamoto Hiroyuki
Publication year - 2007
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1562/2006-03-02-ir-829
Subject(s) - xeroderma pigmentosum , photobiology , photosensitivity , carcinogenesis , dna repair , photodermatosis , gene , biology , dna , microbiology and biotechnology , cancer research , chemistry , genetics , materials science , optoelectronics , botany
The XPA gene‐deficient mouse, an animal model of xeroderma pigmentosum (XP), develops enhanced photobiologic reactions including acute inflammation, immunosuppression and skin carcinogenesis, because of the defect in the excision repair of ultraviolet‐induced DNA lesions. The results strongly suggest that nuclear DNA is an important chromophore to initiate acute and chronic skin damages. The model mouse is a useful experimental animal not only to investigate the mechanisms of photosensitivity in XP, but also to study physiological photobiology in humans, because photobiologic reactions are greatly intensified in this mouse.