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Functional Insights Gained from Structural Analyses of DNA Duplexes that Contain UV‐Damaged Photoproducts †
Author(s) -
Park ChinJu,
Lee JoonHwa,
Choi ByongSeok
Publication year - 2007
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1562/2006-02-28-ir-820
Subject(s) - dna , dna repair , dna clamp , dna damage , dna polymerase , biology , biochemistry , biophysics , chemistry , polymerase chain reaction , gene , reverse transcriptase
Ultraviolet photolesions endow DNA with distinct structural and dynamic properties. Biophysical studies of photoproduct‐containing DNA have shown that these lesions affect the mutagenic properties of DNA and damage recognition by DNA repair systems. Recently obtained high‐resolution co‐crystal structures of damaged DNA bound to either DNA polymerase or DNA repair enzymes have enriched our understanding of the mechanisms by which DNA lesions are bypassed or recognized by DNA metabolizing proteins. Here, we summarize the results of these structural studies and discuss their implications for DNA metabolism.