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Tetrakis(4‐pyridyl)porphyrin Supramolecular Complexes with Cyclodextrins in Aqueous Solution
Author(s) -
Cosma Pinalysa,
Catucci Lucia,
Fini Paola,
Dentuto Pasquale L.,
Agostiano Angela,
Angelini Nicola,
Scolaro Luigi Monsù
Publication year - 2006
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1562/2005-09-26-ra-694
Subject(s) - porphyrin , cyclodextrin , aqueous solution , chemistry , circular dichroism , supramolecular chemistry , fluorescence , fluorescence anisotropy , monomer , absorption (acoustics) , photochemistry , crystallography , organic chemistry , polymer , materials science , crystal structure , biochemistry , physics , quantum mechanics , membrane , composite material
The formation of inclusion complexes of hydroxypropyl‐β‐cyclodextrin, heptakis(2,6‐di‐O‐methyl)‐β‐cyclodextrin and heptakis(2,3,6‐tri‐O‐methyl)‐β‐cyclodextrin with 5,10,15,20‐tetrakis(4‐pyridyl)porphyrin (TpyP) has been studied in aqueous buffer solution (phosphate buffer pH = 7 and I = 0.01 M ) to give a structural and spectroscopic characterization of a new class of potential sensitizers for photodynamic therapy. The interaction was investigated by a combination of UVNis absorption, fluorescence anisotropy, time‐resolved fluorescence and circular dichroism. The experimental results point to the presence of the pigment in water in a monomeric complexed form. The fluorescence anisotropy measurements suggest that TpyP forms 1:1 complexes with heptakis(2,3,6‐tri‐O‐methyl)‐β‐cyclodextrin and hydroxypropyl‐β‐cyclodextrin, while 1:2 complexes are obtained with heptakis(2,6‐di‐O‐methyl)‐β‐cyclodextrin.