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Topical Bioadhesive Patch Systems Enhance Selectivity of Protoporphyrin IX Accumulation
Author(s) -
Donnelly Ryan F.,
Ma LiWei,
Juzenas Petras,
Lani Vladimir,
McCarron Paul A.,
Woolfson A. David,
Moan Johan
Publication year - 2006
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1562/2005-08-08-ra-641
Subject(s) - stratum corneum , bioadhesive , protoporphyrin ix , photodynamic therapy , chemistry , selectivity , cancer research , pharmacology , pathology , biochemistry , medicine , organic chemistry , polymer , catalysis
In clinical 5‐aminolevulinic acid (ALA)‐based photodynamic therapy (PDT) of skin tumors it is desirable to develop vehicles that minimize the penetration of ALA through normal stratum corneum and maximize it through the compromised stratum corneum of the tumors to improve tumor selectivity. We have designed a bioadhesive patch, which may be able to achieve this aim. It induces levels of protoporphyrin IX (PpIX) in skin overlying tumors similar to those induced by the proprietary cream (Porphin®) but at the same time induces less PpIX to form in normal skin and at distant sites. The mechanisms of action of the patch, as compared with that of the cream, were studied by means of Cuprophan® barriers that mimic compromised tumor stratum corneum and in a mouse model with transplanted tumors.