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New Triruthenium Clusters as Photoinduced DNA‐binding and Cleaving Agents ¶
Author(s) -
Ru Hwu Jih,
Lu KuangLieh,
Yu ShengFa,
Yu LeeJu,
Kumaresan Sudalaiandi,
Lin KuanJiun,
Tsay ShwuChen
Publication year - 2002
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1562/0031-8655(2002)0750457ntcapd2.0.co2
Subject(s) - chemistry , dna , biophysics , combinatorial chemistry , biochemistry , biology
1‐Hydroxybenzotriazole and 1‐hydroxypyridine‐2‐thione were incorporated as ligands with the cluster Ru 3 (CO) 10 (NCMe) 2 to give [(μ‐H)Ru 3 (CO) 10 (μ 2 ‐2,3‐η 2 ‐NNN(O)C 6 H 4 )] and [(μ‐H)Ru 3 (CO) 9 (μ 2 ‐η 1 : η 2 ‐C 5 H 4 N(O)S)], respectively. Irradiation of these two new triruthenium metal clusters individually with 350 nm UV light in a phosphate buffer (pH 6.0) containing form I DNA resulted in single‐strand cleavage. Cluster [(μ‐H)Ru 3 (CO) 10 (μ 2 ‐2,3‐η 2 ‐NNN(O)C 6 H 4 )] was also found to bind to calf thymus DNA upon UV irradiation.