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Treatment of Murine Cutaneous Melanoma with Near Infrared Light ¶
Author(s) -
Dees C.,
Harkins J.,
Petersen M. G.,
Fisher W. G.,
Wachter E. A.
Publication year - 2002
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1562/0031-8655(2002)0750296tomcmw2.0.co2
Subject(s) - melanoma , melanoma diagnosis , infrared , dermatology , medicine , cancer research , optics , physics
Treatment of cutaneous melanoma (M‐3 and B16‐F10 implanted in mice) with rapidly‐scanned, tightly‐focused near infrared light elicits selective destruction of tumor tissue. A single laser treatment yielded complete eradication in >90% of B16‐F10 tumors with thicknesses of approximately 3 mm; amelanotic M‐3 tumors proved less responsive ( ca 25% clearance rate). In addition to local tumor destruction, laser treatment of B16‐F10 tumors in immunocompetent mice stimulated enhanced cytokine levels (interleukin‐2 and interleukin‐10) within treated tumor tissues and rejection of tumor cells upon a subsequent challenge dose. Such an antitumor immune response may lead to improved outcomes at both the treatment site and at sites of distant metastasis.