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Photochemical and Photobiological Properties of New Bispsoralen Derivatives (Bis[PsC n ]PIP, n = 4, 6, 8) ¶
Author(s) -
Kim Sung Ki,
Park Han Oh,
Shim Sang Chul
Publication year - 2000
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1562/0031-8655(2000)0720472pappon2.0.co2
Subject(s) - piperazine , intercalation (chemistry) , chemistry , dna , alkyl , irradiation , photochemistry , molecule , combinatorial chemistry , medicinal chemistry , organic chemistry , biochemistry , physics , nuclear physics
Bispsoralen derivatives possessing two psoralens and one piperazine molecule, 1,4‐bis[n′‐(8‐psoralenoxy) alkyl] piperazine (Bis[PsC n ]PIP, n = 4, 6, 8), show high water solubility, efficient intercalation into DNA and good photocrosslinking efficiency of DNA. Bis(PsC 4 )PIP shows high lethality on bacteriophage T7 and can effectively inhibit the amplification of DNA by stopping the polymerase chain reactions in a short period of irradiation time.