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Photosensitization of Red Blood Cell Hemolysis by Lutetium Texaphyrin ¶
Author(s) -
Bilgin Mehmet D.,
AlAkhras MAli,
Khalili Mahmoud,
Hemmati Hila,
Grossweiner Leonard I.
Publication year - 2000
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1562/0031-8655(2000)0720121porbch2.0.co2
Subject(s) - lutetium , hemolysis , incubation , chemistry , kinetics , biophysics , fluence , incubation period , red blood cell , radiochemistry , biochemistry , biology , ion , immunology , physics , organic chemistry , yttrium , quantum mechanics , oxide
Lutetium (III) texaphyrin photosensitizes postirradiation or “delayed” photohemolysis (DPH) of human and bovine red blood cells at 730 nm by a Type‐2 pathway mediated by singlet molecular oxygen. The DPH rate increases with increasing incubation temperature and with the second power of the incident fluence. The experimental DPH curves are in good agreement with a multihit kinetics model based on target theory.