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Synergistic Insecticidal Mode of Action between Sesquiterpene Lactones and a Phototoxin, α‐Terthienyl
Author(s) -
Guillet Gabriel,
Harmatha Juraj,
Waddell Thomas G.,
Philogène Bernard J. R.,
Arnason John T.
Publication year - 2000
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1562/0031-8655(2000)0710111sipsim2.0.co2
Subject(s) - sesquiterpene , chemistry , mode of action , action (physics) , stereochemistry , physics , biochemistry , quantum mechanics
The synergistic insecticidal action of characteristic defensive substances produced by the plant family Asteraceae was investigated under controlled laboratory conditions. Sesquiterpene lactones isolated from Asteraceae that may form, through a Michael addition process, conjugates with glutathione were administered in a meridic diet to a herbivorous insect, Manduca sexta. By administering sesquiterpenes, variable in vivo reduced glutathione levels were observed in the insect larvae. When the Asteraceae‐derived photooxidant α‐terthienyl was co‐administered, lipid peroxidation and larval mortality were significantly enhanced in the treated groups of insects with lowered in vivo glutathione levels.