Open AccessReview of Literature on Akkermansia muciniphila and its Possible Role in the Etiopathogenesis and Therapy of Type 2 Diabetes Mellitus
Author(s) -
Made Indira Dianti Sanjiwani,
I Putu Hendri Aryadi,
I Made Siswadi Semadi
Publication year - 2022
Publication title -
journal of the asean federation of endocrine societies
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.153
H-Index - 3
eISSN - 2308-118X
pISSN - 0857-1074
DOI - 10.15605/jafes.037.01.13
Subject(s) - akkermansia muciniphila , medicine , type 2 diabetes mellitus , insulin resistance , diabetes mellitus , type 2 diabetes , endocrinology , gut flora , immunology
Akkermansia muciniphila is a promising gut microbiota for the treatment of type 2 diabetes mellitus (T2DM). A. muciniphila stimulates intestinal wall integrity, is an anti-inflammatory agent, and reduces endoplasmic reticulum stress, lipogenesis and gluconeogenesis. These properties make A. muciniphila a potential treatment option for T2DM by reducing insulin resistance and increasing insulin sensitivity and glucose tolerance in different tissues. This article explores the possible role of A. muciniphila in T2DM management, along with the various methods known to modulate A. muciniphila .