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Enantioselective addition Of diketene to aldehydes promoted by chiral schiff base—titanium alkoxide complex. Application to asymmetric synthesis of potential inhibitors of HMG coenzyme reductase
Author(s) -
Hayashi Masahiko,
Yoshimoto Kazuya,
Hirata Naohito,
Tanaka Kiyoshi,
Oguni Nobuki,
Harada Katsumasa,
Matsushita Akio,
Kawachi Yasuhiro,
Sasaki Hiroshi
Publication year - 2002
Publication title -
israel journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.908
H-Index - 54
eISSN - 1869-5868
pISSN - 0021-2148
DOI - 10.1560/px53-y9jj-fu8v-gken
Subject(s) - chemistry , enantioselective synthesis , diketene , schiff base , alkoxide , titanium , combinatorial chemistry , organic chemistry , catalysis , stereochemistry
Highly enantioselective addition of diketene to aldehydes was achieved by using novel Schiff base—titanium alkoxide complexes. Up to 92% ee of 5‐hydroxy‐3‐oxoesters was obtained. This procedure provides an efficient method for the asymmetric synthesis of potential inhibitors of HMG coenzyme reductase.