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Design and preparation of polyphenyl distance markers for solid‐state 19 F NMR
Author(s) -
Monde Kenji,
Tomita York,
Gilchrist M. Lane,
McDermott Ann E.,
Nakanishi Koji
Publication year - 2001
Publication title -
israel journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.908
H-Index - 54
eISSN - 1869-5868
pISSN - 0021-2148
DOI - 10.1560/9t7n-k3l6-ttuf-359r
Subject(s) - chemistry , biphenyl , solid state , solid state nuclear magnetic resonance , terphenyl , ligand (biochemistry) , trifluoromethyl , fluorine 19 nmr , nuclear magnetic resonance spectroscopy , analytical chemistry (journal) , stereochemistry , nuclear magnetic resonance , organic chemistry , receptor , biochemistry , physics , alkyl
With 13 C‐labeled samples, it is possible to measure internuclear distances up to 7 Å by solid‐state NMR, thus providing a powerful tool for probing ligand—receptor interactions. However, limitations in measurable distances and appreciable natural abundant 13 C background signals present problems in solid‐state 13 C NMR. In order to overcome these disadvantages, a set of reference compounds with known F—F distances, namely, quinolinol, p ‐biphenyl, and p ‐terphenyl‐bearing trifluoromethyl and trifluoromethylthio groups, have been synthesized. The preparation of these reference compounds and means for diluting these references in solid‐state NMR are described.