Premium
Chiral lewis acid‐catalyzed enantioselective michael reactions in water
Author(s) -
Kobayashi Shū,
Kakumoto Kentaro,
Mori Yuichiro,
Manabe Kei
Publication year - 2002
Publication title -
israel journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.908
H-Index - 54
eISSN - 1869-5868
pISSN - 0021-2148
DOI - 10.1560/6grq-yrvv-6ku3-rhgx
Subject(s) - chemistry , michael reaction , enantioselective synthesis , catalysis , lewis acids and bases , adduct , chiral lewis acid , organic chemistry , binap , addition reaction
Asymmetric Michael reactions of ß‐ketoesters with enones were effectively catalyzed by complexes of silver salts and BINAP derivatives in water. The reactions have proved to give Michael adducts in high yields with high enantioselectivities. These reactions are the first example of Lewis acid‐catalyzed asymmetric Michael reactions in water.