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Synthesis, characterization, and degradation of poly(ester‐anhydride) for particulate delivery
Author(s) -
Modi Sweta,
Jain Jay Prakash,
Kumar Neeraj
Publication year - 2005
Publication title -
israel journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.908
H-Index - 54
eISSN - 1869-5868
pISSN - 0021-2148
DOI - 10.1560/0m15-cnaq-bdr7-xfcm
Subject(s) - sebacic acid , chemistry , lactic acid , polymer , degradation (telecommunications) , biodegradation , biodegradable polymer , polymer chemistry , copolymer , organic chemistry , telecommunications , biology , bacteria , computer science , genetics
A series of poly(ester‐anhydride) from poly(lactic acid) and poly(sebacic acid) have been synthesized and characterized. Poly(lactic acid) of molecular weight 2,550 Da has been synthesized from pharmaceutical grade lactic acid. The copolymers are in the molecular weight range of 3,000‐15,000 Da, with the higher molecular weights obtained for the polymers with higher sebacic acid content. With increase in sebacic acid content, the melting point is also found to increase. The polymers with 50% or more poly(sebacic acid) content melt between 80 and 84 °C. These polymers have been formulated into microspheres and their degradation studied. Due to their biodegradability and the flexibility to alter their degradation profile, they find a wide application in drug delivery.