Open AccessRenal Leiomyosarcoma, a Rare Presentation
Author(s) -
Toukilnan Djiwa,
Kossi Akomola Sabi,
Panakinao Simgban,
Mayi Bombonne,
Bagassam Mézéwè Sama,
Mazamaesso Tchaou,
Tchin Darré
Publication year - 2022
Publication title -
journal of kidney cancer and vhl
Language(s) - English
Resource type - Journals
ISSN - 2203-5826
DOI - 10.15586/jkcvhl.v9i1.216
Subject(s) - leiomyosarcoma , pathology , desmin , immunohistochemistry , medicine , atypia , malignancy , differential diagnosis , cd34 , sarcoma , biology , vimentin , stem cell , genetics
Renal sarcomas are very rare malignant tumours with a very poor prognosis. Renal leiomyosarcoma, a malignant tumour of smooth muscle origin, is the most common histological type. The article reports a case of leiomyosarcoma of renal location, with a review of the literature. A 38-year-old female patient, with no previous pathological history, consulted the nephrology department of the Teaching Hospital of Lomé for abdominal pain that had been present for 4 years. Histology showed a tumour proliferation of fasciculated architecture, made of spindle cells arranged in long bundles, with cytonuclear atypia and cytoarchitectural abnormalities. Immunohistochemical examination showed positive staining for smooth muscle actin, h-caldesmone, desmin and CD34 and negative for pancytokeratin (AE1/AE3), myogenin and PS100. Renal leiomyosarcoma is an exceptional malignancy. It remains the most common renal sarcoma, the differential diagnosis of which is based on immunohistochemical findings.