RAB11A aggravates PDGF-BB-stimulated proliferation, migration, and inflammation of airway smooth muscle cells via affecting the NF-κB and PI3K/AKT pathways | Zendy

Ying Gong | Zendy; Yunhai Hu | Zendy; Jianqiong Huang | Zendy; Haibo Wang | Zendy

Open Access

RAB11A aggravates PDGF-BB-stimulated proliferation, migration, and inflammation of airway smooth muscle cells via affecting the NF-κB and PI3K/AKT pathways

Author(s) -

Ying Gong,

Yunhai Hu,

Jianqiong Huang,

Haibo Wang

Publication year - 2022

Publication title -

allergologia et immunopathologia

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.483

H-Index - 37

eISSN - 1578-1267

pISSN - 0301-0546

DOI - 10.15586/aei.v50i4.635

Subject(s) - pi3k/akt/mtor pathway , protein kinase b , cell growth , medicine , gene knockdown , microbiology and biotechnology , platelet derived growth factor receptor , inflammation , cancer research , signal transduction , immunology , biology , apoptosis , growth factor , receptor , biochemistry

Pediatric asthma is an usual disease and a kind of fearful health threat for children. Airway smooth muscle cells (ASMCs) with increased cell proliferation and migration abilities serve as important features in the progression of asthma. RAB11A has been shown to aggravate cancer progression and is closely associated with inflammation. Gene analysis discovered that RAB11A exhibited higher expression in asthmatic patients. However, the detailed regulatory function of RAB11A in asthma still needs further investigation.

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