CITED2 alleviates lipopolysaccharide-induced inflammation and pyroptosis in - human lung fibroblast by inhibition of NF-κB pathway | Zendy

Xuzhong Zhang | Zendy; Wei Chen | Zendy; Wei Liu | Zendy; Donge Li | Zendy; Wei Shen | Zendy

Open Access

CITED2 alleviates lipopolysaccharide-induced inflammation and pyroptosis in - human lung fibroblast by inhibition of NF-κB pathway

Author(s) -

Xuzhong Zhang,

Wei Chen,

Wei Liu,

Donge Li,

Wei Shen

Publication year - 2022

Publication title -

allergologia et immunopathologia

Language(s) - English

Resource type - Journals

eISSN - 1578-1267

pISSN - 0301-0546

DOI - 10.15586/aei.v50i4.628

Subject(s) - pyroptosis , lipopolysaccharide , western blot , viability assay , medicine , microbiology and biotechnology , inflammation , immunology , biology , cell , inflammasome , biochemistry , gene

Pneumonia, a severe infectious respiratory disease, is one of the leading causes of mortality and morbidity in children. Cbp/P300 interacting transactivator with Glu/Asp-rich carboxy-terminal domain 2 (CITED2) functions as a transcription cofactor, and plays critical roles in the development of embryonic and extra-embryonic tissues, including fetal lung maturation. The present study investigates the role of CITED2 in infantile pneumonia.

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