Open AccessCITED2 alleviates lipopolysaccharide-induced inflammation and pyroptosis in - human lung fibroblast by inhibition of NF-κB pathway
Author(s) -
Xuzhong Zhang,
Wei Chen,
Wei Liu,
Donge Li,
Wei Shen
Publication year - 2022
Publication title -
allergologia et immunopathologia
Language(s) - English
Resource type - Journals
eISSN - 1578-1267
pISSN - 0301-0546
DOI - 10.15586/aei.v50i4.628
Subject(s) - pyroptosis , lipopolysaccharide , western blot , viability assay , medicine , microbiology and biotechnology , inflammation , immunology , biology , cell , inflammasome , biochemistry , gene
Pneumonia, a severe infectious respiratory disease, is one of the leading causes of mortality and morbidity in children. Cbp/P300 interacting transactivator with Glu/Asp-rich carboxy-terminal domain 2 (CITED2) functions as a transcription cofactor, and plays critical roles in the development of embryonic and extra-embryonic tissues, including fetal lung maturation. The present study investigates the role of CITED2 in infantile pneumonia.