Conditioned medium from the bone marrow mesenchymal stem cells modulates immune response via signal transduction and activator of transcription 6 signaling pathway in an allergic rhinitis mouse model | Zendy

Wentao Zou | Zendy; Pei Zou | Zendy; Jiaxiong Zhang | Zendy; Xiaojing Cai | Zendy; Xueying Mao | Zendy; Guangpeng Liu | Zendy

Open Access

Conditioned medium from the bone marrow mesenchymal stem cells modulates immune response via signal transduction and activator of transcription 6 signaling pathway in an allergic rhinitis mouse model

Author(s) -

Wentao Zou,

Pei Zou,

Jiaxiong Zhang,

Xiaojing Cai,

Xueying Mao,

Guangpeng Liu

Publication year - 2022

Publication title -

allergologia et immunopathologia

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.483

H-Index - 37

eISSN - 1578-1267

pISSN - 0301-0546

DOI - 10.15586/aei.v50i4.572

Subject(s) - medicine , immunology , allergic inflammation , immunoglobulin e , ovalbumin , mesenchymal stem cell , bone marrow , mucous membrane of nose , inflammation , immune system , sensitization , antibody , pathology

Allergic rhinitis (AR) is a common immune disease of the nasal mucosa characterized with immunoglobulin E (IgE)-mediated allergic inflammation after exposure to allergens in susceptible population. Previous reports have demonstrated that the bone marrow mesenchymal stem cells (BMSCs) could reduce allergic inflammation. However, there is little knowledge about whether the culture supernatant of BMSCs (conditioned medium, CM) has similar anti- inflammatory potential in treating AR.

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