Open Accesslnc-THRIL and miR-125b relate to disease risk, severity, and imbalance of Th1 cells/Th2 cells in allergic rhinitis
Author(s) -
Jihye Song,
Dan Liú,
Weizhi Yin
Publication year - 2022
Publication title -
allergologia et immunopathologia
Language(s) - English
Resource type - Journals
eISSN - 1578-1267
pISSN - 0301-0546
DOI - 10.15586/aei.v50i3.528
Subject(s) - medicine , rhinorrhea , immune system , immunology , disease , itching , real time polymerase chain reaction , microrna , proinflammatory cytokine , nasal congestion , gastroenterology , inflammation , nose , gene , biochemistry , chemistry , anatomy
Tumor necrosis factor and HNRNPL-related immunoregulatory long noncoding RNA (lnc-THRIL) and its target microRNA (miR)-125b are reported to regulate immune response through several means by participating in allergic rhinitis (AR) pathology. This study aimed to investigate the role of lnc-THRIL and miR-125b in detecting AR risk, and to further explore their correlation with disease severity and cytokines released from T helper type (Th) 1 and Th2 in AR patients.