Momordica charantia L. improves airway hyperresponsiveness and suppresses inflammation in a murine model of allergic asthma | Zendy

Clara do Prado Lopes Frota | Zendy; Alessa Castro Ribeiro | Zendy; Marco Túlio Alvarenga Calil Filho | Zendy; Lucas Junqueira de Freitas Morel | Zendy; Leandra Naíra Zambelli Ramalho | Zendy; Jéssica Cristina Amaral | Zendy; Sílvia Helena Taleb Contini | Zendy; Vanessa Maciel Bráulio da Fonseca | Zendy; Marcos de Carvalho Borges | Zendy; Ana Maria Soares Pereira | Zendy; Fábio Carmona | Zendy

Open Access

Momordica charantia L. improves airway hyperresponsiveness and suppresses inflammation in a murine model of allergic asthma

Author(s) -

Clara do Prado Lopes Frota,

Alessa Castro Ribeiro,

Marco Túlio Alvarenga Calil Filho,

Lucas Junqueira de Freitas Morel,

Leandra Naíra Zambelli Ramalho,

Jéssica Cristina Amaral,

Sílvia Helena Taleb Contini,

Vanessa Maciel Bráulio da Fonseca,

Marcos de Carvalho Borges,

Ana Maria Soares Pereira,

Fábio Carmona

Publication year - 2022

Publication title -

allergologia et immunopathologia

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.483

H-Index - 37

eISSN - 1578-1267

pISSN - 0301-0546

DOI - 10.15586/aei.v50i2.577

Subject(s) - medicine , ovalbumin , bronchoalveolar lavage , momordica , dexamethasone , lung , asthma , immunology , inflammation , in vivo , saline , pharmacology , traditional medicine , immune system , biology , microbiology and biotechnology

To evaluate the effect of a hydroethanolic extract of Momordica charantia L. ("bitter melon", Cucurbitaceae) leaves (MCHA) on ovalbumin (OVA)-induced asthma model. Balb/c mice were sensitized twice and challenged for 4 alternate days with OVA and then treated with MCHA (500 mg/kg) for 7 consecutive days.

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