Taxifolin ameliorates sepsis-induced lung capillary leak through inhibiting the JAK/STAT3 pathway | Zendy

Mengwen Shen | Zendy; Baibai Lin | Zendy; Fenghua Qian | Zendy; Lei Zhao | Zendy; Yao Xi | Zendy; Yiming Qian | Zendy

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Taxifolin ameliorates sepsis-induced lung capillary leak through inhibiting the JAK/STAT3 pathway

Author(s) -

Mengwen Shen,

Baibai Lin,

Fenghua Qian,

Lei Zhao,

Yao Xi,

Yiming Qian

Publication year - 2022

Publication title -

allergologia et immunopathologia

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.483

H-Index - 37

eISSN - 1578-1267

pISSN - 0301-0546

DOI - 10.15586/aei.v50i2.550

Subject(s) - medicine , sepsis , janus kinase , bronchoalveolar lavage , lung , western blot , lipopolysaccharide , immunology , pharmacology , cytokine , biology , biochemistry , gene

As a systemic inflammatory reaction, sepsis is associated with various organ dysfunctions. The capillary leakage and the imbalance between T helper 17 and regulatory T (Th17/Treg) cells are associated with sepsis-induced lung injury. Taxifolin (TXL) has been found to play a vital role in regulating this diverse disease. However, the detailed functioning and mechanism of TXL in regulating sepsis-induced lung capillary leak remain elusive.

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