Dexmedetomidine represses TGF-β1-induced extracellular matrix production and proliferation of airway smooth muscle cells by inhibiting MAPK signaling pathway | Zendy

Rong Zhou | Zendy; Xiaohong Chen | Zendy

Open Access

Dexmedetomidine represses TGF-β1-induced extracellular matrix production and proliferation of airway smooth muscle cells by inhibiting MAPK signaling pathway

Author(s) -

Rong Zhou,

Xiaohong Chen

Publication year - 2022

Publication title -

allergologia et immunopathologia

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.483

H-Index - 37

eISSN - 1578-1267

pISSN - 0301-0546

DOI - 10.15586/aei.v50i2.505

Subject(s) - viability assay , cell growth , medicine , extracellular matrix , transforming growth factor , mapk/erk pathway , endocrinology , p38 mitogen activated protein kinases , apoptosis , signal transduction , microbiology and biotechnology , biology , biochemistry

Airway remodeling is implicated in the pathogenesis of asthma, and abnormal proliferation of airway smooth muscle cells (ASMCs) contribute to airway remodeling. Inflammatory mediator, transforming growth factor-β1 (TGF-β1), stimulates the proliferation of ASMCs, and is associated with airway remodeling in asthma. Dexmedetomidine (DEX) has been widely used in the adjuvant therapy of acute asthma.

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