Open AccessCombination therapy of specific aeroallergens immunotherapy and omalizumab, in children with severe asthma
Author(s) -
Laura Valdesoiro Navarrete,
María Esther León,
Marcos Julia Rodriguez,
Martina Indiveri,
Roser Ayats,
H. Larramona,
Miguel González,
Oscar A. Cruz,
Montserrat Bosque García
Publication year - 2022
Publication title -
allergologia et immunopathologia
Language(s) - English
Resource type - Journals
eISSN - 1578-1267
pISSN - 0301-0546
DOI - 10.15586/aei.v50i2.469
Subject(s) - medicine , omalizumab , asthma , adverse effect , pediatrics , population , etiology , medical record , immunoglobulin e , immunology , antibody , environmental health
Background: In most cases, severe asthma in children has an allergic etiology, but allergen-specific immunotherapy (AIT) is contraindicated.Objective: This study aimed at analyzing the safety and efficacy of AIT in patients with severe asthma treated with omalizumab (OM).Methods: A descriptive real-life study was carried out by reviewing medical records. Effectiveness was measured by the degree of control (CAN questionnaire), number of hospitalizations per year, number of exacerbations per year, and maintenance treatment and lung function (FEV1). Some adverse reactions occurred (AAI-EAACI-WAO guidelines).Results: The retrospective study included 29 patients up to 18 years of age with severe asthma with OM plus AIT treatment. AIT treatment was started in a cluster schedule when patients treated with OM achieved disease control. Before starting AIT, patients were treated with OM for 1 year for achieving asthmatic control. AIT to mites (51%), Alternaria (37.9%), or pollens (10.3%) was administered. After one year with OM plus AIT,statistically significant differences in CAN scores and FEV1 measures were observed (P < 0.001). No patients under treatment with OM plus AIT required hospital admission. During the clustering schedule, only 3/64 doses showed systemic adverse reactions. During the AIT maintenance treatment, 348 doses were administered, with no significant adverse reactions.Conclusion: In this population-based study in children with severe asthma, the combined treatment with OM plus AIT was safe and effective. This strategy allows these pediatric patients to be safely treated with AIT.